Male Comprehensive Profile II — Advanced Male Hormone & Metabolic Health Testing
Male Comprehensive Profile II is a comprehensive saliva-based hormone and metabolic health panel that provides advanced insight into the key drivers of men's health, aging, vitality, and hormonal balance. This panel measures estradiol (E2), testosterone (T), DHEA-S (DS), SHBG, PSA, TSH, free T3 (fT3), and free T4 (fT4) — providing an in-depth picture of hormonal and thyroid function.
What's Included in This Panel

Estradiol (E2) — evaluates estrogen levels critical for bone density and cardiovascular health in men
Testosterone (T) — measures free and total testosterone for libido, muscle mass, and vitality
DHEA-S (DS) — adrenal marker supporting energy, immune function, and anti-aging
SHBG — sex hormone binding globulin affecting testosterone bioavailability
PSA — prostate-specific antigen for prostate health monitoring
TSH, fT3, fT4 — comprehensive thyroid function assessment

Who Should Order This Test?
This profile is ideal for men experiencing fatigue, low libido, reduced muscle mass, mood changes, weight gain, or suspected hormonal imbalances associated with andropause (male menopause). It provides a complete hormonal baseline for men seeking to optimize their health and longevity. Results are reviewed by Michelle Tonkin ND.
Frequently Asked Questions
Q: Why saliva testing instead of blood?
A: Saliva testing measures the "free" or bioavailable fraction of hormones — the portion that is actually active in your tissues. This often provides more clinically relevant information than total blood hormone levels.
Q: How do I collect my sample?
A: A test kit with collection instructions is provided. Most tests require morning saliva collection, and some require multiple timed collections throughout the day.
Q: How are results delivered?
A: Results are provided with a practitioner review and recommendations from Michelle Tonkin ND to help you understand and act on your findings.