Male Comprehensive Profile I — Detailed Male Hormone & Thyroid Health Assessment
Male Comprehensive Profile I is a comprehensive saliva-based hormone and metabolic health panel measuring estradiol (E2), testosterone (T), DHEA-S (DS), cortisol (4-point Cx4), PSA, TSH, fT3, and fT4. This detailed assessment provides an in-depth analysis of male hormonal balance, thyroid function, adrenal health, and prostate marker — giving men the complete hormonal picture needed for evidence-based natural health support.
What's Measured

Estradiol (E2) — monitors estrogen levels critical for bone density and cardiovascular health in men
Testosterone (T) — evaluates free and total testosterone for vitality, libido, and muscle maintenance
DHEA-S (DS) — adrenal androgen supporting energy, immunity, and anti-aging
Cortisol x4 (Cx4) — full 4-point daily cortisol rhythm for adrenal health assessment
PSA — prostate-specific antigen for prostate health monitoring
TSH, fT3, fT4 — comprehensive thyroid function panel

Who Should Order This Profile?
This profile is ideal for men over 35, those experiencing fatigue, decreased libido, reduced muscle mass, mood changes, weight gain, or symptoms of andropause. It combines hormone, thyroid, and adrenal assessment in a single comprehensive panel. Results reviewed by Michelle Tonkin ND with a personalized natural health protocol.
Frequently Asked Questions
Q: How does this differ from Male Comprehensive Profile II?
A: Profile I includes full 4-point cortisol (Cx4) for comprehensive adrenal assessment, while Profile II uses a single-point cortisol. Profile I is recommended when adrenal fatigue or cortisol rhythm issues are suspected alongside hormonal concerns.
Q: Is at-home saliva testing accurate?
A: Yes — saliva hormone testing for free hormones is well-validated and used widely in research. It provides particularly accurate free (bioavailable) testosterone and cortisol measurements.