Female Comprehensive Profile I — Complete Women's Hormone, Adrenal & Thyroid Panel
Female Comprehensive Profile I is a comprehensive saliva-based hormone and metabolic health panel measuring estradiol (E2), progesterone (Pg), testosterone (T), DHEA-S (DS), 4-point cortisol (Cx4), and thyroid markers (TSH, fT3, fT4). This all-encompassing panel provides the most detailed picture of female hormonal health — combining sex hormone balance, adrenal rhythm, and thyroid function in a single, convenient test.
What's Measured

Estradiol (E2) — reproductive health, bone density, mood, and cardiovascular protection
Progesterone (Pg) — estrogen balance, sleep quality, uterine and breast health
Testosterone (T) — libido, energy, lean mass, and cognitive drive
DHEA-S (DS) — adrenal androgen for energy, immunity, and vitality
Cortisol x4 (Cx4) — full diurnal cortisol rhythm assessment
TSH, fT3, fT4 — comprehensive thyroid function markers

Who Is This For?
Female Comprehensive Profile I is the most thorough test for women experiencing complex hormonal issues affecting multiple systems: hormonal imbalance + adrenal dysfunction + thyroid problems together. It is ideal for perimenopausal and menopausal women, women with Hashimoto's and hormonal symptoms, those with chronic fatigue, and anyone wanting a complete hormonal foundation before beginning a natural health protocol. Results reviewed by Michelle Tonkin ND.
Frequently Asked Questions
Q: How does this compare to Female Comprehensive Profile II?
A: Profile I includes the 4-point cortisol rhythm (Cx4) for comprehensive adrenal assessment, while Profile II offers more hormone markers but a single cortisol reading. Profile I is ideal when adrenal dysfunction and hormonal imbalance are both present.
Q: Can this help with perimenopause management?
A: Absolutely — perimenopause often involves simultaneous changes in estrogen, progesterone, cortisol, and thyroid. This panel captures all of these changes for a complete clinical picture.