5-MTHF 15 mg – 30 Capsules (Thorne)
Thorne's 5-MTHF 15 mg is the highest-potency active methylfolate available — used under practitioner supervision for individuals with compound heterozygous or homozygous MTHFR mutations causing significant methylation pathway impairment. At 15 mg, this dose is typically reserved for clinical correction of severely elevated homocysteine, treatment-resistant depression linked to folate deficiency, autism spectrum support protocols, or complex neurological conditions. Should always be taken alongside active B12 (methylcobalamin or adenosylcobalamin) to prevent methyl-trapping. A 30-day supply at this potency level. Practitioner guidance strongly recommended.
Dose: 15 mg High-Potency Methylfolate • Homozygous MTHFR Protocol • 30-Day Supply • Clinical Strength • Practitioner Supervision Advised
Best For
5 is best for everyday wellness, nutritional gaps, and whole-body health support. It is especially well-suited for individuals seeking a professional, practitioner-vetted supplement as part of a holistic wellness routine.
How to Use
Take as directed on the label or by your healthcare practitioner. Always follow the label directions or guidance from your healthcare provider. Do not exceed the recommended dose.
Frequently Asked Questions
- Is 5 third-party tested? All products at Healthy Solutions For All meet practitioner-grade standards for purity and potency.
- Who recommends this product? 5 is curated by Michelle Tonkin ND and Melissa Tonkin CNC, twin sisters with 20+ years of holistic clinical experience.
- Can I get personalized guidance? Yes — book a free 10-minute consultation to find out if this product is right for your health goals.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

